o8G Site-Specifically Modified tRF-1-AspGTC: A Novel Therapeutic Target and Biomarker for Pulmonary Hypertension. Circulation Research. 2024 NEW!
Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification. Nature Communications. 2024 NEW!
Targeting SOX13 inhibits assembly of respiratory chain supercomplexes to overcome ferroptosis resistance in gastric cancer. Nature Communications. 2024 NEW!
The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4. Advanced Science. 2024 NEW!
METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs. International Journal of Oral Science. 2024 NEW!
A Novel tsRNA, m7G-3′ tiRNA Lys TTT, Promotes Bladder Cancer Malignancy Via Regulating ANXA2 Phosphorylation. Advanced Science. 2024 NEW!
METTL3-mediated pre-miR-665/DLX3 m6A methylation facilitates the committed differentiation of stem cells from apical papilla. Experimental & Molecular Medicine. 2024 NEW!
m7G-modified mt-tRF3b-LeuTAA regulates mitophagy and metabolic reprogramming via SUMOylation of SIRT3 in chondrocytes. Biomaterials. 2024 NEW!
Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition. Journal of Hazardous Materials. 2024 NEW!
WTAP/YTHDF1-mediated m6A modification amplifies IFN-γ-induced immunosuppressive properties of human MSCs. Journal of Advanced Research. 2024 NEW!
tsRNA-GlyGCC promotes colorectal cancer progression and 5-FU resistance by regulating SPIB. Journal of Experimental & Clinical Cancer Research. 2024 NEW!
m6A modification of lncRNA PHKA1-AS1 enhances Actinin Alpha 4 stability and promotes non-small cell lung cancer metastasis. MedComm. 2024 NEW!
METTL3 regulates M6A methylation-modified EBV-pri-miR-BART3-3p to promote NK/T cell lymphoma growth. Cancer Letters. 2024 NEW!
CircUGGT2 downregulation by METTL14-dependent m6A modification suppresses gastric cancer progression and cisplatin resistance through interaction with miR 186-3p/MAP3K9 axis. Pharmacological Research. 2024 NEW!
N6 methyladenosine modified SRPK1 promotes aerobic glycolysis of lung adenocarcinoma via PKM splicing. Cellular & Molecular Biology Letters. 2024 NEW!
FTO/IGF2BP2-mediated N6 methyladenosine modification in invasion and metastasis of thyroid carcinoma via CDH12. Cell Death & Disease. 2024 NEW!
METTL4 mediated-N6-methyladenosine promotes acute lung injury by activating ferroptosis in alveolar epithelial cells. Free Radical Biology and Medicine. 2024 NEW!
Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop. Acta Pharmacologica Sinica. 2024 NEW!
Sirt1 m6A modification-evoked Leydig cell senescence promotes Cd-induced testosterone decline. Ecotoxicology and Environmental Safety. 2024 NEW!
m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA. Cell & Bioscience. 2024 NEW!
M6A RNA methylation-mediated TUG1 stability maintains mitochondrial homeostasis during kidney aging by epigenetically regulating PGC1-α expression. Antioxidants & Redox Signaling. 2024 NEW!
TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis. Cell Biology and Toxicology. 2024 NEW!
Dysregulation of pseudouridylation in small RNAs contributes to papillary thyroid carcinoma metastasis. Cancer Cell International. 2024 NEW!
RNA N6-methyladenosine modificationbased biomarkers for absorbed ionizing radiation dose estimation. Nature Communications. 2023
Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice. Journal of Hazardous Materials. 2023
Specific RNA m6A modification sites in bone marrow mesenchymal stem cells from the jawbone marrow of type 2 diabetes patients with dental implant failure. International Journal of Oral Science. 2023
KIAA1429 promotes tumorigenesis and gefitinib resistance in lung adenocarcinoma by activating the JNK/ MAPK pathway in an m6A-dependent manner. Drug Resistance Updates. 2023
Therapeutic m6 A Eraser ALKBH5 mRNA[1]Loaded Exosome−Liposome Hybrid Nanoparticles Inhibit Progression of Colorectal Cancer in Preclinical Tumor Models. ACS nano. 2023
FTO-dependent m6 A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke. Nature Communications. 2023
Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice. Journal of Hazardous Materials. 2023
METTL3-mediated m6A modifcation of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing. Journal of Translational Medicine. 2023
The role of N6 -methyladenosine modification in benzene-induced testicular damage and the protective effect of melatonin. Chemosphere. 2023
N6 -methyladenosine plays a dual role in arsenic carcinogenesis by temporal-specific control of core target AKT1. Journal of Hazardous Materials. 2022
PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase. The EMBO Journal. 2022
METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis , Molecular Cancer . 2022
METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma. eBioMedicine. 2022
Methyltransferase-like 3 leads to lung injury by up-regulation of interleukin 24 through N6-methyladenosine-dependent mRNA stability and translation efficiency in mice exposed to fine particulate matter 2.5. Environmental Pollution. 2022
METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis , Molecular Cancer . 2022
METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer . Molecular Cancer . 2022
WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis . Cell Death & Differentiation . 2022
METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis . Journal of Experimental & Clinical Cancer Research . 2022
m6A‐mediated regulation of PBX1‐GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels . Cancer Communications . 2022
M6A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression . Oncogene . 2022
The Combined Effects of circRNA Methylation Promote Pulmonary Fibrosis . American Journal of Respiratory Cell and Molecular Biology . 2022
ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1 . Theranostics . 2021
RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent . Journal of Experimental & Clinical Cancer Research . 2021
ALKBH5-mediated m6A mRNA Methylation Governs Human Embryonic Stem Cell Cardiac Commitment . Molecular Therapy-Nucleic Acids . 2021
ALKBH5 suppresses tumor progression via an m 6 A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma . Cell Death & Disease . 2021
RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes . Cell Death & Disease . 2021
The potential roles of m6 A modification in regulating the inflammatory response in microglia . Journal of Neuroinflammation . 2021
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N 6-methyladenosine methylation of Parp10 mRNA . Nature Cell Biology . 2020
YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer " . Molecular cancer . 2020
NADP modulates RNA m 6 A methylation and adipogenesis via enhancing FTO activity . Nature Chemical Biology . 2020
N6-Methyladenosine Modification of Fatty Acid Amide Hydrolase Messenger RNA in Circular RNA STAG1-Regulated Astrocyte Dysfunction and Depressive-like Behaviors. . Biological Paychiatry . 2020
SIRT1 regulates N6‐methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2‐dependent FTO SUMOylation . Hepatology . 2020
m6A methylation of precursor-miR-320/RUNX2 controls osteogenic potential of bone marrow-derived mesenchymal stem cells . Molecular Therapy-Nucleic Acids . 2019
KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3 . Molecular Cancer . 2019
METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance. . Gut . 2019
Genome-wide screening of altered m6A-tagged transcript profiles in the hippocampus after traumatic brain injury in mice . Epigenomics . 2019
