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单细胞测序技术服务 靶向lncRNA单细胞全转录组测序 单细胞全转录组测序 |
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生物分子凝聚体研究 HyPro靶RNA临近标记技术 |
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RNA-蛋白相互作用 HyPro - MS CHIRP – MS RNA pull-down MS |
RNA-RNA/DNA相互作用 HyPro-seq/芯片 CHIRP-seq |
蛋白-RNA相互作用 AGO APP seq/芯片 RIP-RNA seq/芯片 |
蛋白-蛋白相互作用 RIME MS CoIP-MS |
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NGS测序技术服务 R-loop 测序分析服务 |
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NGS测序技术服务 环状DNA测序 |
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基因芯片技术服务 Small RNA修饰芯片 m6A单碱基分辨率芯片 mRNA&lncRNA表观转录组芯片 circRNA表观转录组芯片 |
NGS测序技术服务 表观转录组学测序服务 RNA m6A甲基化测序（MeRIP Seq） |
LC-MS mRNA碱基修饰检测 tRNA碱基修饰检测 |
PCR技术服务 MeRIP-PCR技术服务 m6A绝对定量RT-PCR技术服务 m6A单碱基位点PCR（MazF酶切法）技术服务 |
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Ribo-seq Ribo seq |
核糖体-新生肽链复合物(RNC) RNC联合 circRNA芯片 RNC联合 lncRNA芯片 RNC联合mRNA-seq |
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蛋白表达定量 Label free非标定量技术 TMT标记定量技术 PRM靶向定量 |
RNA N6-methyladenosine modificationbased biomarkers for absorbed ionizing radiation dose estimation. Nature Communications. 2023 NEW!
Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice. Journal of Hazardous Materials. 2023 NEW!
Specific RNA m6A modification sites in bone marrow mesenchymal stem cells from the jawbone marrow of type 2 diabetes patients with dental implant failure. International Journal of Oral Science. 2023 NEW!
KIAA1429 promotes tumorigenesis and gefitinib resistance in lung adenocarcinoma by activating the JNK/ MAPK pathway in an m6A-dependent manner. Drug Resistance Updates. 2023 NEW!
Therapeutic m6 A Eraser ALKBH5 mRNA[1]Loaded Exosome−Liposome Hybrid Nanoparticles Inhibit Progression of Colorectal Cancer in Preclinical Tumor Models. ACS nano. 2023 NEW!
FTO-dependent m6 A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke. Nature Communications. 2023
Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice. Journal of Hazardous Materials. 2023
METTL3-mediated m6A modifcation of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing. Journal of Translational Medicine. 2023
The role of N6 -methyladenosine modification in benzene-induced testicular damage and the protective effect of melatonin. Chemosphere. 2023
N6 -methyladenosine plays a dual role in arsenic carcinogenesis by temporal-specific control of core target AKT1. Journal of Hazardous Materials. 2022
PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase. The EMBO Journal. 2022
METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis , Molecular Cancer . 2022
METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma. eBioMedicine. 2022
Methyltransferase-like 3 leads to lung injury by up-regulation of interleukin 24 through N6-methyladenosine-dependent mRNA stability and translation efficiency in mice exposed to fine particulate matter 2.5. Environmental Pollution. 2022
METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis , Molecular Cancer . 2022
METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer . Molecular Cancer . 2022
WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis . Cell Death & Differentiation . 2022
METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis . Journal of Experimental & Clinical Cancer Research . 2022
m6A‐mediated regulation of PBX1‐GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels . Cancer Communications . 2022
M6A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression . Oncogene . 2022
The Combined Effects of circRNA Methylation Promote Pulmonary Fibrosis . American Journal of Respiratory Cell and Molecular Biology . 2022
ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1 . Theranostics . 2021
RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent . Journal of Experimental & Clinical Cancer Research . 2021
ALKBH5-mediated m6A mRNA Methylation Governs Human Embryonic Stem Cell Cardiac Commitment . Molecular Therapy-Nucleic Acids . 2021
ALKBH5 suppresses tumor progression via an m 6 A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma . Cell Death & Disease . 2021
RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes . Cell Death & Disease . 2021
The potential roles of m6 A modification in regulating the inflammatory response in microglia . Journal of Neuroinflammation . 2021
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N 6-methyladenosine methylation of Parp10 mRNA . Nature Cell Biology . 2020
YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer " . Molecular cancer . 2020
NADP modulates RNA m 6 A methylation and adipogenesis via enhancing FTO activity . Nature Chemical Biology . 2020
N6-Methyladenosine Modification of Fatty Acid Amide Hydrolase Messenger RNA in Circular RNA STAG1-Regulated Astrocyte Dysfunction and Depressive-like Behaviors. . Biological Paychiatry . 2020
SIRT1 regulates N6‐methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2‐dependent FTO SUMOylation . Hepatology . 2020
m6A methylation of precursor-miR-320/RUNX2 controls osteogenic potential of bone marrow-derived mesenchymal stem cells . Molecular Therapy-Nucleic Acids . 2019
KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3 . Molecular Cancer . 2019
METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance. . Gut . 2019
Genome-wide screening of altered m6A-tagged transcript profiles in the hippocampus after traumatic brain injury in mice . Epigenomics . 2019
