单细胞测序技术服务 单细胞全转录组测序 |
NGS测序技术服务 环状DNA测序 |
基因芯片技术服务 Small RNA修饰芯片 m6A单碱基分辨率芯片 mRNA&lncRNA表观转录组芯片 circRNA表观转录组芯片 |
NGS测序技术服务 RNA m6A甲基化测序(MeRIP Seq) |
LC-MS mRNA碱基修饰检测 tRNA碱基修饰检测 |
PCR技术服务 MeRIP-PCR技术服务 m6A绝对定量RT-PCR技术服务 m6A单碱基位点PCR(MazF酶切法)技术服务 |
基因芯片技术服务 DNA甲基化芯片 DNA羟甲基化芯片 ChIP-chip |
NGS测序技术服务 DNA甲酰基胞嘧啶(5fc)修饰测序 DNA 5hmC 测序(化学法) DNA甲基化测序 DNA羟甲基化测序 染色质免疫共沉淀测序 |
PCR技术服务 MeDIP-qPCR hMeDIP-qPCR ChIP-qPCR |
蛋白相对定量 TMT标记定量技术 非标定量技术 |
蛋白修饰 TMT标记定量磷酸化 非标定量磷酸化 |
RNA/蛋白-蛋白相互作用 HyPro靶RNA临近标记技术 RNA-蛋白相互作用 蛋白-蛋白相互作用 |
DNA hydroxymethylation reprogramming of β-oxidation genes mediates early-life arsenic-evoked hepatic lipid accumulation in adult mice . Journal of Hazardous Materials . 2022
Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription. Journal of Hepatology . 2021
Oncogenic role of SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2 positive diffuse large B-cell lymphomas. Blood . 2021
Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain. Nature communications . 2021
DNA methylation and hydroxymethylation associated with gene expression regulatory network during 3-methylcholanthrene induced lung cell malignant transformation. Science of The Total Environment . 2021
Paternal exposure to microcystin-LR triggers developmental neurotoxicity in zebrafish offspring via an epigenetic mechanism involving MAPK pathway. Science of The Total Environment . 2021
Calcitonin gene‐related peptide induces the histone H3 lysine 9 acetylation in astrocytes associated with neuroinflammation in rats with neuropathic pain. CNS Neuroscience & Therapeutics . 2021
Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain. Journal of neuroinflammation . 2021
BRD4 inhibition alleviates mechanical stress-induced TMJ OA-like pathological changes and attenuates TREM1-mediated inflammatory response. Clinical Epigenetics . 2021
Histone demethylase KDM6A promotes somatic cell reprogramming by epigenetically regulating the PTEN and IL‐6 signal pathways . STEM CELLS . 2020
Multi-generational obesogenic effects of sulfomethoxazole on Caenorhabditis elegans through epigenetic regulation . Journal of Hazardous Materials . 2019
Interplay of miR-137 and EZH2 contributes to the genome-wide redistribution of H3K27me3 underlying the Pb-induced memory impairment . Cell death & disease . 2019
The detrimental effects of glucocorticoids exposure during pregnancy on offspring’s cardiac functions mediated by hypermethylation of bone morphogenetic protein-4[ . Cell death & disease . 2018
The LINK-A lncRNA interacts with PtdIns (3, 4, 5) P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Lin A, et al. Nature Cell Biology, 2017
A novel lncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern. Sun T T, et al. Cancer discovery, 2016
Integrative Transcriptome Analyses of Metabolic Responses in Mice Define Pivotal LncRNA Metabolic Regulators.Yang L, et al. Cell Metabolism, 2016.
Differential transcriptome expression in human nucleus accumbens as a function of loneliness. Canli T, et al. Molecular Psychiatry, 2016
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011
CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell. 2012
Hypoxia Inducible Factor 2 Alpha Inhibits Hepatocellular Carcinoma Growth Through the Transcription Factor Dimerization Partner 3/ E2F Transcription Factor 1–Dependent Apoptotic Pathway. HEPATOLOGY. 2013
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription. PNAS. 2013
Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China. PNAS. 2013
The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. Proc Natl Acad Sci U S A. 2009