表观遗传研究

国内学者使用康成表观遗传服务发表的SCI成果

Histone demethylase KDM6A promotes somatic cell reprogramming by epigenetically regulating the PTEN and IL‐6 signal pathways . STEM CELLS . 2020

Multi-generational obesogenic effects of sulfomethoxazole on Caenorhabditis elegans through epigenetic regulation . Journal of Hazardous Materials . 2019

Interplay of miR-137 and EZH2 contributes to the genome-wide redistribution of H3K27me3 underlying the Pb-induced memory impairment . Cell death & disease . 2019

The detrimental effects of glucocorticoids exposure during pregnancy on offspring’s cardiac functions mediated by hypermethylation of bone morphogenetic protein-4[ . Cell death & disease . 2018

The LINK-A lncRNA interacts with PtdIns (3, 4, 5) P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Lin A, et al. Nature Cell Biology, 2017 
A novel lncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern. Sun T T, et al. Cancer discovery, 2016

Integrative Transcriptome Analyses of Metabolic Responses in Mice Define Pivotal LncRNA Metabolic Regulators.Yang L, et al.  Cell Metabolism, 2016.

Differential transcriptome expression in human nucleus accumbens as a function of loneliness. Canli T, et al. Molecular Psychiatry, 2016

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011
CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell. 2012

Hypoxia Inducible Factor 2 Alpha Inhibits Hepatocellular Carcinoma Growth Through the Transcription Factor Dimerization Partner 3/ E2F Transcription Factor 1–Dependent Apoptotic Pathway. HEPATOLOGY. 2013

Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription. PNAS. 2013

Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China. PNAS. 2013

The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. Proc Natl Acad Sci U S A. 2009


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